I'm assuming you're going to use tempered glass for the front? That's the first thing I'd do is start scrounging for tempered glass. If you have to buy it new, the economy of the homebuilt panel goes in the toilet. At $75/lb for cells, it's already getting there. You can cut your backing plate to size, you cannot cut tempered glass.
Definitely go at least 36 cells. Some of my Vocs with 36 were around 19V and I notice commercial panels are often around 21V so I'd bet that 38 or even possibly 40 cells per panel would work well.
I'd only attach the cells to the backing in one place. The expansion and contraction of the cells vs the material you mount them to would likely stress and crack the cells if you attach them at the corners, at least that's my theory.
Aluminum scares me because it's conductive and there's a bunch of electricity running around on the backs of these cells. Screw something up with the spacers and you make a dead short, not necessairly dangerous but possibly hard to repair.
I studied everyone else's method and still prefer my own. I've made up 600 watts of 100W panels now and a couple of 50W ones. They have not been outside in the weather at all yet so my designs are untested. If you search my postings, you'll find my methods, probably in diaries.
