I guess the only interesting question is what to use for seals and the main bearings.
Having recently disassembled a grenaded transmission, it wouldn't surprise me if the right transmission could be found that has fully supported shafts and seals on both sides.
I think a great alternative to standard chain is the roller chain found in certain vehicles.
I have a double roller chain and sprockets from a toyota 21R engine that would probably last a lot longer than the standard chain, supposing cheap replacements could be found. --these could be pulled out at a junkyard for little effort, but would cost quite a bit buying them new.
Another more exotic option would be the gear chains, aka link chains. --but these will only be found in 2:1 ratios.. if you want to run two in series to get 4:1 that's an option but 3:1 is probably more useful than 4, due to startup friction.
While more expensive initially, the roller or link chains would last a lot longer.
However you can buy 10 feet of double wide #35 chain for 15$, and that should be enough for three sets of chains.
--are you intending to install a brake?
If you intend to use those spherical self aligning four bolt flanges, then you don't even have to line the bold holes up, and you can bolt the flange to the inside of a weldment.. drilling the holes after welding it together.