Anything from Toyota will probably hold its value better than the Honda and Ford variants. Since nobody wants to pay royalties on a patented system, or admit that they are using the exact same system from some other company in their products, every company varies the method of integrating the engine/electric motor.
The latest buzz is about a "plug-in" hybrid. By increasing the size of the (expensive) battery pack, (and also changing to a more advanced type) the car can be driven as a pure electric vehicle for about thirty minutes. This means 90% of the time you won't burn any fuel at all, but the gasoline engine is still there if you need to drive on a long trip. The Prius' sytem configuration is more easily adapted to becoming a plug-in hybrid, making them more desireable a few years down the road.
There's a company (I think its "Hymotion"?) that will install a large Li-ion battery pack (replacing the small NiMH pack) and adjust the power management computer (voiding the warrantee) for $17,000. Because of the warrantee being voided, it is usually being done to 5 year old Priuses, which are just now becoming available in noticeable quantities.
I commend you on committing to spending a significant amount of money to buy a car that will reduce fuel use and pollution. You will be well-served by any one of the high-quality Honda, Ford, or Toyota hybrid cars.
Might I suggest that you look into, and seriously consider, a 2008 VW Diesel Golf/Jetta?
They get around 50 MPG and are easily convertible to running on FREE, American-grown, and non-polluting used vegetable oil from restaurants (WVO), while still maintaining the ability to run on Diesel or Bio-diesel on long trips.
Diesels are well-known to reliably run over 200K miles, and an automatic transmission rebuild is much cheaper than a hybrid battery pack replacement.
Either way, a hybrid or Diesel is a good choice in my opinion. -Ron
"Electricians do it without shorts until it Hertz"