I have a 40-year-old RV ammonia refrigerator that is 3-way, on 12VDC it is a battery flattening behemoth, and will run a 30-lb tank dry way too fast unless you're a weekend warrior. There are better units, a very good unit uses 1.7 gallon per week for a 14.4 cuft w/ 4.7 cu ft freezer (30x36x68") but runs $2500 delivered - their smallest uses a gallon a week (24x30x64" - 8/2.1 cuft) and runs about $1750 delivered.
I also have a 12/24V compressor run mini-fridge but they aren't really built for 24/7365 usage - Seals, trim, shelves are all flimsy, and the internal voltage inverter is as fragile as any inverter and costs a bunch if/when they fail.
Converting a 120VAC chest freezer into a cooler and running it off a high efficiency pure sine inverter sure might be the most efficient way.